NSJ Bioreagents

T-bet Antibody (TBX21)

Product Code:
 
NSJ-R31106
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
After reconstitution, the T-bet antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of T-bet antbody and human recombinant protein, 35KD with tag; Lane 1: 5ng; 2: 2.5ng; 3: 1.25ng
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Western blot testing of T-bet antbody and human recombinant protein, 35KD with tag; Lane 1: 5ng; 2: 2.5ng; 3: 1.25ng

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CodeSizePrice
NSJ-R31106-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the T-bet antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
TBX21 (T-Box 21), also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Zhang and Yang(2000) mapped the mouse Tbx21 gene to chromosome 11D in an area showing homology of synteny with human chromosome 17. Szabo et al.(2000) showed that expression correlates with IFNG expression in Th1 and natural killer(NK) cells. Ectopic expression of T-bet both transactivated the IFNG gene and induced endogenous IFNG production. Finotto et al.(2002) observed reduced expression of the T(H)1 transcription factor T-bet in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss might be associated with asthma.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human T-box expressed in T cells (DKEAEGQFYNYFPN) was used as the immunogen for this T-bet antibody.
Limitation:
This T-bet antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
Q9UL17