NSJ Bioreagents

PPAR gamma Antibody

Product Code:
 
NSJ-R30380
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
After reconstitution, the PPAR gamma antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of PPAR gamma antibody and Lane 1: MM453; 2: MM231; 3: HeLa; 4: Jurkat; 5: HT1080 cell lysate

Western blot testing of PPAR gamma antibody and Lane 1: MM453; 2: MM231; 3: HeLa; 4: Jurkat; 5: HT1080 cell lysate

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NSJ-R30380-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting points. Titration of the PPAR gamma antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
The peroxisome proliferator-activated receptors are a group of three nuclear receptor isoforms, PPAR gamma, alpha, delta, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs) within promoters. PPAR gamma is a transcription factor that has a pivotal role in adipocyte differentiation and expression of adipocyte-specific genes. Isoforms 1 and 2 result from alternative splicing and have ligand-dependent and -independent activation domains. PPAR gamma is a member of a family of nuclear receptors/ligand-dependent transcription factors, which bind to hormone response elements on target gene promoters. Ameshima et al.(2003) found that it is abundantly expressed in normal lung tissues, especially in endothelial cells, but that its expression is reduced or absent in the angiogenic plexiform lesions of pulmonary hypertensive lungs and in the vascular lesions of a rat model of severe pulmonary hypertension. And they conclude that fluid shear stress decreases its expression in endothelial cells and that loss of expression characterizes an abnormal, proliferating, apoptosis-resistant endothelial cell phenotype.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acis 45-62 (PHYEDIPFTRTDPVVADY-human) were used as the immunogen for this PPAR gamma antibody.
Limitation:
This PPAR gamma antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
P37231