Doublecortin Antibody / DBCN / DCX

Western blot: 0.5-1ug/ml

Optimal dilution of the DCX antibody should be determined by the researcher.

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide

Neuronal migration protein Doublecortin, also known as Doublin or Lissencephalin-X, is a protein that in humans is encoded by the DCX gene. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Amino acids 74-100 (QSLRFHQNMELDFGHFDERDKTSRNMR-human) were used as the immunogen for the DCX antibody.

This antibody is available for research use only.

Antigen affinity

Human, Mouse, Rat

O43602