CSF3R Antibody / Colony Stimulating Factor 3 Receptor

Western blot: 0.5-1ug/ml

The stated application concentrations are suggested starting amounts. Titration of the CSF3R antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Colony-Stimulating Factor 3 Receptor, Granulocyte also known as GCSFR or CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

Antigen affinity purified

0.5mg/ml if reconstituted with 0.2ml sterile DI water

An amino acid sequence from the middle region of human CSF3R (EPWQPGLHINQKCELRHK) was used as the immunogen for this CSF3R antibody.

This CSF3R antibody is available for research use only.

Antigen affinity

Human

Q99062