NSJ Bioreagents

CD168 Antibody

Product Code:
 
NSJ-R30670
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
After reconstitution, the CD168 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of CD168 antibody and Lane 1: MM231; 2: MM453; 3: HeLa; 4: A549 cell lysate~
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IHC-P: CD168 antibody testing of human placenta tissue
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Western blot testing of CD168 antibody and Lane 1: MM231; 2: MM453; 3: HeLa; 4: A549 cell lysate~
IHC-P: CD168 antibody testing of human placenta tissue

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NSJ-R30670-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the CD168 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
CD168, or HMMR (Hyaluronan-mediated motility receptor), is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, CD168 does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. It normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of CD168 to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, it associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, it associates with CD44, and upon binding to HA, activates intracellular signaling pathways.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
An amino acid sequence from the C-terminus of human CD168 (KEGNTNCYRAPMECQESWK) was used as the immunogen for this CD168 antibody.
Limitation:
This CD168 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
O75330