NSJ Bioreagents

Caspase-12 Antibody

Product Code:
 
NSJ-R31215
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
After reconstitution, the Caspase-12 antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of Caspase-12 antibody; Lane 1: PANC; 2: SMMC-7721; 3: A549; 4: HeLa
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IHC-P: Caspase-12 antibody testing of human breast cancer tissue
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IHC-P: Caspase-12 antibody testing of human lung cancer tissue
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Western blot testing of Caspase-12 antibody; Lane 1: PANC; 2: SMMC-7721; 3: A549; 4: HeLa
IHC-P: Caspase-12 antibody testing of human breast cancer tissue
IHC-P: Caspase-12 antibody testing of human lung cancer tissue

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CodeSizePrice
NSJ-R31215-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting points. Titration of the Caspase-12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Caspase-12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Caspase-12 attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of its expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids 71-84 (KIFREHLWNSKKQL-human) were used as the immunogen for this Caspase-12 antibody.
Limitation:
This Caspase-12 antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human
Uniprot #:
Q6UXS9