NSJ Bioreagents

CaMKK Antibody

Product Code:
 
NSJ-R30595
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
After reconstitution, the CaMKK antibody can be stored for up to one month at 40. For long-term, aliquot and store at -200. Avoid repeated freezing and thawing.
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Western blot testing of CaMKK antibody and Lane 1: rat brain; 2: mouse brain~
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IHC-P: CaMKK antibody testing of rat brain tissue
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Western blot testing of CaMKK antibody and Lane 1: rat brain; 2: mouse brain~
IHC-P: CaMKK antibody testing of rat brain tissue

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NSJ-R30595-100ug100 ug£535.00
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Further Information

Application Details :
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml
Application Note:
The stated application concentrations are suggested starting amounts. Titration of the CaMKK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. CaMKK binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. It catalyzed a 10-fold increase in the total activity of CaMK1 and had no effect on CaMK2. Cotransfection of COS-7 cells with CaMKK and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that CaMKK enhances Camk4-mediated transcriptional regulation.
Format :
Antigen affinity purified
Formulation :
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
Amino acids 10-31 (QDPRAELVDRVAAINVAHLEEA-mouse) were used as the immunogen for this CaMKK antibody.
Limitation:
This CaMKK antibody is available for research use only.
Purity:
Antigen affinity
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
Q8VBY2