ProSci

Mouse Acvr1c Antibody

Product Code:
 
PSI-57-853
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse heart tissue lysates (35ug/lane).
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Western blot analysis in mouse heart tissue lysates (35ug/lane).

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PSI-57-853-400ul400ul£626.00
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Further Information

Additional Names:
Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH287801}
Application Note:
For WB starting dilution is: 1:1000
Background:
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Background References:
  • Andersson, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7252-7256(2008)
  • Bertolino, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7246-7251(2008)
  • Liguori, G.L., et al. Dev. Biol. 315(2):280-289(2008)
  • Kurrasch, D.M., et al. J. Neurosci. 27(50):13624-13634(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Human, Rat
Immunogen:
This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of mouse Acvr1c.
NCBI Gene ID #:
269275
NCBI Official Name:
Activin receptor type-1C
NCBI Official Symbol:
Acvr1c
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
Q8K348
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
Q8K348
User NOte:
Optimal dilutions for each application to be determined by the researcher.