Further Information
Signal transducer and activator of transcription 5B, STAT5B
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
- Xi, S., et al., Cancer Res. 63(20):6763-6771 (2003).
- Uddin, S., et al., Biochem. Biophys. Res. Commun. 308(2):325-330 (2003).
- Zhang, X., et al., J. Allergy Clin. Immunol. 112(1):93-101 (2003).
- Yamashita, H., et al., Oncogene 22(11):1638-1652 (2003).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Pig
This STAT5b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.
6777
Signal transducer and activator of transcription 5B
STAT5B
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
P51692
41019536
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Cell Cycle,Obesity,Signal Transduction
P51692
Optimal dilutions for each application to be determined by the researcher.