Further Information
Double-strand-break repair protein rad21 homolog, hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog, RAD21, HR21, KIAA0078, NXP1
For WB starting dilution is: 1:2000
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
- McKay M.J.,et al.Genomics 36:305-315(1996).
- Sadano H.,et al.Biochem. Biophys. Res. Commun. 267:418-422(2000).
- Nomura N.,et al.DNA Res. 1:223-229(1994).
- Ota T.,et al.Nat. Genet. 36:40-45(2004).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine
This RAD21 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 501-535 amino acids from human RAD21.
5885
Double-strand-break repair protein rad21 homolog
RAD21
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
72 kDa
O60216
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle
O60216
Optimal dilutions for each application to be determined by the researcher.