Further Information
GTP-binding nuclear protein Ran, Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, RAN, ARA24
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
RAN (ras-related nuclear protein) is a small GTP binding
protein belonging to the RAS superfamily that is essential for the
translocation of RNA and proteins through the nuclear pore complex.
The RAN protein is also involved in control of DNA synthesis and
cell cycle progression. Nuclear localization of RAN requires the
presence of regulator of chromosome condensation 1 (RCC1).
Mutations in RAN disrupt DNA synthesis. Because of its many
functions, it is likely that RAN interacts with several other
proteins. RAN regulates formation and organization of the
microtubule network independently of its role in the
nucleus-cytosol exchange of macromolecules. RAN could be a key
signaling molecule regulating microtubule polymerization during
mitosis. RCC1 generates a high local concentration of RAN-GTP
around chromatin which, in turn, induces the local nucleation of
microtubules. RAN is an androgen receptor (AR) coactivator that
binds differentially with different lengths of polyglutamine within
the androgen receptor. Polyglutamine repeat expansion in the AR is
linked to Kennedy's disease (X-linked spinal and bulbar muscular
atrophy). RAN coactivation of the AR diminishes with polyglutamine
expansion within the AR, and this weak coactivation may lead to
partial androgen insensitivity during the development of Kennedy's
disease.
- Kim, J.S., et al. Mol. Carcinog. 49(10):913-921(2010)
- Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)
- Boni, V., et al. Pharmacogenomics J. (2010) In press :
- Ly, T.K., et al. J. Biol. Chem. 285(8):5815-5826(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Drosophila, Monkey, Rat, Xenopus
This RAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the Central region of human RAN.
5901
GTP-binding nuclear protein Ran
RAN
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
P62826
51338598
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Signal Transduction
P62826
Optimal dilutions for each application to be determined by the researcher.