ProSci

SOST Antibody

Product Code:
 
PSI-59-168
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western Blot at 1:500 dilution + human kidney lysate Lysates/proteins at 20 ug per lane.
2 / 2
Western blot analysis in mouse liver tissue lysates (35ug/lane).
❮❯

Western Blot at 1:500 dilution + human kidney lysate Lysates/proteins at 20 ug per lane.
Western blot analysis in mouse liver tissue lysates (35ug/lane).

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PSI-59-168-400ul400ul£626.00
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Further Information

Additional Names:
Sclerostin, SOST
Application Note:
For WB starting dilution is: 1:500
Background:
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq].
Background References:
  • van Lierop, A.H., et al. Eur. J. Endocrinol. 163(5):833-837(2010)
  • Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
  • Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
  • Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.
NCBI Gene ID #:
50964
NCBI Official Name:
Sclerostin
NCBI Official Symbol:
SOST
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
Q9BQB4
Protein GI Number:
20140220
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q9BQB4
User NOte:
Optimal dilutions for each application to be determined by the researcher.