Further Information
Macrophage metalloelastase, MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12, MMP12, HME
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.
- Nar, H., et al., J. Mol. Biol. 312(4):743-751 (2001).
- Lang, R., et al., J. Mol. Biol. 312(4):731-742 (2001).
- Gronski, T.J. Jr., et al., J. Biol. Chem. 272(18):12189-12194 (1997).
- Shapiro, S.D., et al., J. Biol. Chem. 268(32):23824-23829 (1993).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This MMP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12.
4321
Macrophage metalloelastase
MMP12
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
P39900
729179
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
P39900
Optimal dilutions for each application to be determined by the researcher.