ProSci

Tyrosyl tRNA synthetase Antibody

Product Code:
 
PSI-63-010
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of anti-YARS Pab in Jurkat cell line lysates (35ug/lane)
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Western blot analysis of anti-YARS Pab in Jurkat cell line lysates (35ug/lane)

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PSI-63-010-400ul400ul£626.00
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Further Information

Additional Names:
Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS, Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed, YARS
Application Note:
For WB starting dilution is: 1:1000
Background:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
Background References:
  • Yang,X.L., Chem. Biol. 14 (12), 1323-1333 (2007)
  • Jordanova,A., Nat. Genet. 38 (2), 197-202 (2006)
  • Bonnefond,L., Biochemistry 44 (12), 4805-4816 (2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This Tyrosyl tRNA synthetase (YARS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-190 amino acids from the N-terminal region of human Tyrosyl tRNA synthetase (YARS).
NCBI Gene ID #:
8565
NCBI Official Name:
Tyrosine--tRNA ligase, cytoplasmic
NCBI Official Symbol:
YARS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
59 kDa
Protein Accession #:
P54577
Protein GI Number:
13638438
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Swissprot #:
P54577
User NOte:
Optimal dilutions for each application to be determined by the researcher.