ProSci

POLK Antibody

Product Code:
 
PSI-60-812
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in 293 cell line lysates (35ug/lane).
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Western blot analysis in 293 cell line lysates (35ug/lane).

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PSI-60-812-400ul400ul£626.00
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Further Information

Additional Names:
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Application Note:
For WB starting dilution is: 1:1000
Background:
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).
Background References:
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
  • Katafuchi, A., et al. Nucleic Acids Res. 38(3):859-867(2010)
  • Fukuda, H., et al. J. Biol. Chem. 284(38):25585-25592(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This POLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the Central region of human POLK.
NCBI Gene ID #:
51426
NCBI Official Name:
DNA polymerase kappa
NCBI Official Symbol:
POLK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
99 kDa
Protein Accession #:
Q9UBT6
Protein GI Number:
59798438
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UBT6
User NOte:
Optimal dilutions for each application to be determined by the researcher.