Further Information
Transcription initiation factor TFIID subunit 10, STAF28, Transcription initiation factor TFIID 30 kDa subunit, TAF(II)30, TAFII-30, TAFII30, TAF10, TAF2A, TAF2H, TAFII30
For WB starting dilution is: 1:1000
Initiation of transcription by RNA polymerase II requires
the activities of more than 70 polypeptides. The protein that
coordinates these activities is transcription factor IID (TFIID),
which binds to the core promoter to position the polymerase
properly, serves as the scaffold for assembly of the remainder of
the transcription complex, and acts as a channel for regulatory
signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated
factors or TAFs. TAFs may participate in basal transcription, serve
as coactivators, function in promoter recognition or modify general
transcription factors (GTFs) to facilitate complex assembly and
transcription initiation. This gene encodes one of the small
subunits of TFIID that is associated with a subset of TFIID
complexes. Studies with human and mammalian cells have shown that
this subunit is required for transcriptional activation by the
estrogen receptor, for progression through the cell cycle, and may
also be required for certain cellular differentiation programs.
- Egloff, S., et al. J. Biol. Chem. 285(27):20564-20569(2010)
- Ma, Y., et al. J. Biol. Chem. 285(13):9813-9822(2010)
- Zhao, Y., et al. Mol. Cell 29(1):92-101(2008)
- Hao, H., et al. Oncogene 26(57):7872-7884(2007)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This TAF10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human TAF10.
6881
Transcription initiation factor TFIID subunit 10
TAF10
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Q12962
3024688
This antibody is purified through a protein A column, followed by peptide affinity purification.
Q12962
Optimal dilutions for each application to be determined by the researcher.