Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Histone-lysine N-methyltransferase SUV39H2, Histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2, KMT1B
For WB starting dilution is: 1:1000
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
- Sun, X.J., et al. PLoS ONE(1), E1499 (2008) :
- Wu, C., et al. Proteomics 7(11):1775-1785(2007)
- Yoon, K.A., et al. Carcinogenesis 27(11):2217-2222(2006)
- Frontelo, P., et al. Oncogene 23(30):5242-5251(2004)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Monkey, Mouse
This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-395 amino acids from the C-terminal region of human SUV39H2.
79723
Histone-lysine N-methyltransferase SUV39H2
SUV39H2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Q9H5I1
25091325
This antibody is purified through a protein A column, followed by peptide affinity purification.
Q9H5I1
Optimal dilutions for each application to be determined by the researcher.