ProSci

SAP18 Antibody

Product Code:
 
PSI-58-153
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in K562 cell line lysates (35ug/lane).
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Western blot analysis in K562 cell line lysates (35ug/lane).

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PSI-58-153-400ul400ul£626.00
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Further Information

Additional Names:
Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18, SAP18
Application Note:
For WB starting dilution is: 1:1000
Background:
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
Background References:
  • Sorin, M., et al. PLoS Pathog.(6), E1000463 (2009) :
  • McCallum, S.A., et al. Biochemistry 45(39):11974-11982(2006)
  • Joselin, A.P., et al. J. Biol. Chem. 281(18):12475-12484(2006)
  • Schwerk, C., et al. Mol. Cell. Biol. 23(8):2981-2990(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human SAP18.
NCBI Gene ID #:
10284
NCBI Official Name:
Histone deacetylase complex subunit SAP18
NCBI Official Symbol:
SAP18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
18 kDa
Protein Accession #:
O00422
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O00422
User NOte:
Optimal dilutions for each application to be determined by the researcher.