ProSci

PDE8A Antibody

Product Code:
 
PSI-57-875
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of PDE8A Antibody (L572) in HL60 cell line lysates (35ug/lane)
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Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PDE8A antibody (L572), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis of PDE8A Antibody (L572) in HL60 cell line lysates (35ug/lane)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PDE8A antibody (L572), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-57-875-400ul400ul£626.00
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Further Information

Additional Names:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50
Background:
PDE8A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Background References:
  • Wu,P., Proc. Natl. Acad. Sci. U.S.A. 101 (51), 17634-17639 (2004)
  • Gamanuma,M., Cell. Signal. 15 (6), 565-574 (2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PDE8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from the Central region of human PDE8A.
NCBI Gene ID #:
5151
NCBI Official Name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
NCBI Official Symbol:
PDE8A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
93 kDa
Protein Accession #:
O60658
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
O60658
User NOte:
Optimal dilutions for each application to be determined by the researcher.