Further Information
Histone deacetylase 7, HD7, Histone deacetylase 7A, HD7a, HDAC7, HDAC7A
For WB starting dilution is: 1:1000
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual
substrate specificity and function in vivo.
- Meinke PT and Liberator P. Curr Med Chem, 8(2): 211- 235 (2001).
- Nakayamaand Takami Y.Biochem (Tokyo) 129 (4): 491-499 (2001).
- Cress, W.D. and Seto, E. J. Cell. Physiol. 184, 1-16 (2000).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This HDAC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 920-952 amino acids from the C-terminal region of human HDAC7.
51564
Histone deacetylase 7
HDAC7
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
103 kDa
Q8WUI4
30913097
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Signal Transduction
Q8WUI4
Optimal dilutions for each application to be determined by the researcher.