Further Information
Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin-1, DON-1, Neural- and thymus-derived activator for ERBB kinases, NTAK, NRG2, NTAK
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
- Yamada, K., et al., Gene 255(1):15-24 (2000). Ring, H.Z., et al., Hum. Genet. 104(4):326-332 (1999). Busfield, S.J., et al., Mol. Cell. Biol. 17(7):4007-4014 (1997). Higashiyama, S., et al., J. Biochem. 122(3):675-680 (1997). Carraway, K.L. III, et al., Nature 387(6632):512-516 (1997).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat
This NRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2.
9542
Pro-neuregulin-2, membrane-bound isoform
NRG2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
92 kDa
O14511
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Neuroscience,Signal Transduction
O14511
Optimal dilutions for each application to be determined by the researcher.