ProSci

Connexin 50 Antibody

Product Code:
 
PSI-58-183
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of anti-GJA8 Antibody in HepG2 cell line lysates (35ug/lane)
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Western blot analysis of anti-GJA8 Antibody in HepG2 cell line lysates (35ug/lane)

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PSI-58-183-400ul400ul£626.00
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Further Information

Additional Names:
Gap junction alpha-8 protein, Connexin-50, Cx50, Lens fiber protein MP70, GJA8
Application Note:
For WB starting dilution is: 1:1000
Background:
GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.
Background References:
  • Shiels, A., et al., Am. J. Hum. Genet. 62(3):526-532 (1998).
  • Church, R.L., et al., Curr. Eye Res. 14(10):979-981 (1995).
  • Church, R.L., et al., Curr. Eye Res. 14(3):215-221 (1995).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-130 amino acids from the N-terminal region of human Connexin 50.
NCBI Gene ID #:
2703
NCBI Official Name:
Gap junction alpha-8 protein
NCBI Official Symbol:
GJA8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
P48165
Protein GI Number:
13124697
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P48165
User NOte:
Optimal dilutions for each application to be determined by the researcher.