ProSci

Connexin 30.3 Antibody

Product Code:
 
PSI-58-177
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of GJB4 using rabbit polyclonal GJB4 Antibody (H105.Connexin) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GJB4 gene.
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Western blot analysis of GJB4 using rabbit polyclonal GJB4 Antibody (H105.Connexin) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GJB4 gene.

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PSI-58-177-400ul400ul£626.00
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Further Information

Additional Names:
Gap junction beta-4 protein, Connexin-303, Cx303, GJB4
Application Note:
For WB starting dilution is: 1:1000
Background:
Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.
Background References:
  • Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
  • Richard, G., et al., J. Invest. Dermatol. 120(4):601-609 (2003).
  • Macari, F., et al., Am. J. Hum. Genet. 67(5):1296-1301 (2000).
  • Lopez-Bigas, N., et al., Hum. Mutat. 19 (4), 458 (2002).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Connexin 30.3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-120 amino acids from the N-terminal region of human Connexin 30.3.
NCBI Gene ID #:
127534
NCBI Official Name:
Gap junction beta-4 protein
NCBI Official Symbol:
GJB4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
30 kDa
Protein Accession #:
Q9NTQ9
Protein GI Number:
12229761
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q9NTQ9
User NOte:
Optimal dilutions for each application to be determined by the researcher.