ProSci

TRPC4 Antibody

Product Code:
 
PSI-58-703
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).

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PSI-58-703-400ul400ul£626.00
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Further Information

Additional Names:
Short transient receptor potential channel 4, TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4
Application Note:
For WB starting dilution is: 1:1000
Background:
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Background References:
  • Mace, K.E., et al. J. Cell. Physiol. 225(2):444-453(2010)
  • von Spiczak, S., et al. Neuromolecular Med. 12(3):292-299(2010)
  • Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This TRPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 812-840 amino acids from the C-terminal region of human TRPC4.
NCBI Gene ID #:
7223
NCBI Official Name:
Short transient receptor potential channel 4
NCBI Official Symbol:
TRPC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
112 kDa
Protein Accession #:
Q9UBN4
Protein GI Number:
13633994
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q9UBN4
User NOte:
Optimal dilutions for each application to be determined by the researcher.