ProSci

PTPIA2 beta Antibody

Product Code:
 
PSI-63-465
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody is used in Western blot to detect PTPIA2 beta in C6 cell lysate.
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Antibody is used in Western blot to detect PTPIA2 beta in C6 cell lysate.

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PSI-63-465-400ul400ul£626.00
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Further Information

Additional Names:
Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387
Application Note:
For WB starting dilution is: 1:1000
Background:
PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.
Background References:
  • Schmidli, R.S., et al., Autoimmunity 28(1):15-23 (1998).
  • Li, Q., et al., Proc. Assoc. Am. Physicians 109(4):429-439 (1997).
  • Cui, L., et al., J. Biol. Chem. 271(40):24817-24823 (1996).
  • Kawasaki, E., et al., Biochem. Biophys. Res. Commun. 227(2):440-447 (1996).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PTPIA2 beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-125 amino acids from the N-terminal region of human PTPIA2 beta.
NCBI Gene ID #:
5799
NCBI Official Name:
Receptor-type tyrosine-protein phosphatase N2
NCBI Official Symbol:
PTPRN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
111 kDa
Protein Accession #:
Q92932
Protein GI Number:
116242738
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Immunology,Signal Transduction
Swissprot #:
Q92932
User NOte:
Optimal dilutions for each application to be determined by the researcher.