ProSci

MIST Antibody

Product Code:
 
PSI-57-368
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in HepG2 cell line lysates (35ug/lane).
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Western blot analysis in HepG2 cell line lysates (35ug/lane).

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PSI-57-368-400ul400ul£626.00
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Further Information

Additional Names:
Cytokine-dependent hematopoietic cell linker, Mast cell immunoreceptor signal transducer, CLNK, MIST
Application Note:
For WB starting dilution is: 1:1000
Background:
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).
Background References:
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)
  • Goitsuka, R., et al. J. Biol. Chem. 276(38):36043-36050(2001)
  • Goitsuka, R., et al. Int. Immunol. 12(4):573-580(2000)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MIST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-308 amino acids from the Central region of human MIST.
NCBI Gene ID #:
116449
NCBI Official Name:
Cytokine-dependent hematopoietic cell linker
NCBI Official Symbol:
CLNK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q7Z7G1
Protein GI Number:
166217263
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
Q7Z7G1
User NOte:
Optimal dilutions for each application to be determined by the researcher.