ProSci

OAS3 Antibody

Product Code:
 
PSI-62-190
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody is used in Western blot to detect OAS3 in A375 lysate.
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Antibody is used in Western blot to detect OAS3 in A375 lysate.

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PSI-62-190-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
2'-5'-oligoadenylate synthase 3, (2-5')oligo(A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS, OAS3
Application Note:
For WB starting dilution is: 1:1000
Background:
OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.
Background References:
  • Ito, M., et al., Cancer Res. 61(5):2038-2046 (2001). Rebouillat, D., et al., Genomics 70(2):232-240 (2000). Rebouillat, D., et al., J. Biol. Chem. 274(3):1557-1565 (1999).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This OAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1087 amino acids from the C-terminal region of human OAS3.
NCBI Gene ID #:
4940
NCBI Official Name:
2'-5'-oligoadenylate synthase 3
NCBI Official Symbol:
OAS3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
121 kDa
Protein Accession #:
Q9Y6K5
Protein GI Number:
317373408
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Immunology
Swissprot #:
Q9Y6K5
User NOte:
Optimal dilutions for each application to be determined by the researcher.