Further Information
HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1, HLA-DPA1, HLA-DP1A, HLASB
For WB starting dilution is: 1:1000
HLA-DPA1 belongs to the HLA class II alpha chain
paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta (DPB) chain, both anchored in the
membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II
molecules are expressed in antigen presenting cells (APC: B
lymphocytes, dendritic cells, macrophages). The alpha chain is
approximately 33-35 kDa and its gene contains 5 exons. Exon one
encodes the leader peptide, exons 2 and 3 encode the two
extracellular domains, exon 4 encodes the transmembrane domain and
the cytoplasmic tail. Within the DP molecule both the alpha chain
and the beta chain contain the polymorphisms specifying the peptide
binding specificities, resulting in up to 4 different molecules.
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Varney, M.D., et al. Diabetes 59(8):2055-2062(2010)
- Ovsyannikova, I.G., et al. PLoS ONE(7), E11806 (2010) :
- Mychaleckyj, J.C., et al. Clin Trials(1 SUPPL), S75-S87 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This HLA-DPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the C-terminal region of human HLA-DPA1.
3113
HLA class II histocompatibility antigen, DP alpha 1 chain
HLA-DPA1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
P20036
122204
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology
P20036
Optimal dilutions for each application to be determined by the researcher.