Further Information
Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, Complement C4 beta chain, Complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, Complement C4 gamma chain, C4A, CO4, CPAMD2
For WB starting dilution is: 1:2000
This gene encodes the basic form of complement factor 4,
part of the classical activation pathway. The protein is expressed
as a single chain precursor which is proteolytically cleaved into a
trimer of alpha, beta, and gamma chains prior to secretion. The
trimer provides a surface for interaction between the
antigen-antibody complex and other complement components. The alpha
chain may be cleaved to release C4 anaphylatoxin, a mediator of
local inflammation. Deficiency of this protein is associated with
systemic lupus erythematosus. This gene localizes to the major
histocompatibility complex (MHC) class III region on chromosome 6.
Varying haplotypes of this gene cluster exist, such that
individuals may have 1, 2, or 3 copies of this gene. In addition,
this gene exists as a long form and a short form due to the
presence or absence of a 6.4 kb endogenous HERV-K retrovirus in
intron 9.
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Fernando, M.M., et al. Hum. Mutat. 31(7):866-874(2010)
- Mostafa, G.A., et al. J. Neuroimmunol. 223 (1-2), 115-119 (2010) :
- Hamad, O.A., et al. J. Immunol. 184(5):2686-2692(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This C4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the Central region of human C4B.
720, 721
Complement C4-A
C4A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
193 kDa
P0C0L4
476007827
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology
P0C0L4
Optimal dilutions for each application to be determined by the researcher.