ProSci

PON1 Antibody

Product Code:
 
PSI-55-339
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of lysate from human blood plasma tissue lysate, using PON1 Antibody at 1:1000 at each lane.
2 / 3
Flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
3 / 3
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Western blot analysis of lysate from human blood plasma tissue lysate, using PON1 Antibody at 1:1000 at each lane.
Flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

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PSI-55-339-400ul400ul£626.00
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Further Information

Additional Names:
Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON
Application Note:
For WB starting dilution is: 1:1000

For FACS starting dilution is: 1:10~50

For IHC-P starting dilution is: 1:10~50
Background:
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
Background References:
  • Ergun, M.A., et al. Biochem. Genet. (2010) In press :
  • Cagirci, G., et al. J. Heart Valve Dis. 19(4):453-458(2010)
  • Mendonca, M.I., et al. Rev Port Cardiol 29(4):571-580(2010)
  • Hashemi, M., et al. Genet. Mol. Res. 9(3):1735-1741(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PON1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-145 amino acids from the Central region of human PON1.
NCBI Gene ID #:
5444
NCBI Official Name:
Serum paraoxonase/arylesterase 1
NCBI Official Symbol:
PON1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 kDa
Protein Accession #:
P27169
Protein GI Number:
308153572
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Obesity,Neuroscience,Signal Transduction
Swissprot #:
P27169
User NOte:
Optimal dilutions for each application to be determined by the researcher.