Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
- Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)
- Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)
- Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2.
148738
Hemojuvelin
HFE2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Q6ZVN8
51316254
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Obesity,Neuroscience,Signal Transduction
Q6ZVN8
Optimal dilutions for each application to be determined by the researcher.