Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1
For WB starting dilution is: 1:1000
The nuclear lamina consists of a two-dimensional matrix of
proteins located next to the inner nuclear membrane. The lamin
family of proteins make up the matrix and are highly conserved in
evolution. During mitosis, the lamina matrix is reversibly
disassembled as the lamin proteins are phosphorylated. Lamin
proteins are thought to be involved in nuclear stability, chromatin
structure and gene expression. Vertebrate lamins consist of two
types, A and B. Through alternate splicing, this gene encodes three
type A lamin isoforms. Mutations in this gene lead to several
diseases: Emery-Dreifuss muscular dystrophy, familial partial
lipodystrophy, limb girdle muscular dystrophy, dilated
cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
progeria syndrome.
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Wegner, L., et al. J. Clin. Endocrinol. Metab. 95(8):3884-3892(2010)
- Drac, H., et al. Neurol. Neurochir. Pol. 44(3):291-296(2010)
- Liu, Q., et al. PLoS ONE(5), E10874 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.
4000
Prelamin-A/C
LMNA
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
74 kDa
P02545
125962
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Cell Cycle,Signal Transduction
P02545
Optimal dilutions for each application to be determined by the researcher.