ProSci

CD320 Antibody

Product Code:
 
PSI-56-874
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in U251 cell line lysates (35ug/lane).
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Western blot analysis in U251 cell line lysates (35ug/lane).

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PSI-56-874-400ul400ul£626.00
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Further Information

Additional Names:
CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Application Note:
For WB starting dilution is: 1:1000
Background:
The CD320 antigen gene encodes the transcobalamin receptor (TCBLR). Cellular uptake of cobalamin (vitamin B12) is mediated by receptors expressed on the cell surface. Transcobalamin II (TCN2; MIM 613441), a plasma protein secreted by endothelial cells, binds the cobalamin absorbed in the distal ileum and carries 10 to 30% of total circulating cobalamin. CD320 encodes a transcobalamin receptor that binds TCN2-cobalamin at the plasma membrane and internalizes the complex by endocytosis (Quadros et al., 2009 [PubMed 18779389]).
Background References:
  • Jiang, W., et al. Gene 466 (1-2), 49-55 (2010) :
  • Pangilinan, F., et al. J. Med. Genet. 47(10):677-685(2010)
  • Quadros, E.V., et al. Hum. Mutat. 31(8):924-929(2010)
  • Quadros, E.V., et al. Blood 113(1):186-192(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.
NCBI Gene ID #:
51293
NCBI Official Name:
CD320 antigen
NCBI Official Symbol:
CD320
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
Q9NPF0
Protein GI Number:
74734303
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Cell Cycle,Immunology
Swissprot #:
Q9NPF0
User NOte:
Optimal dilutions for each application to be determined by the researcher.