Further Information
26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, Antisecretory factor 1, AF, ASF, Multiubiquitin chain-binding protein, PSMD4, MCB1
For IHC-P starting dilution is: 1:50~100
For WB starting dilution is: 1:1000
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSDM4 one of the non-ATPase subunits of the 19S regulator lid.
- Walters, K.J., et al., Biochemistry 41(6):1767-1777 (2002).
- Kawahara, H., et al., EMBO J. 19(15):4144-4153 (2000).
- Tanahashi, N., et al., J. Biol. Chem. 275(19):14336-14345 (2000).
- Johansson, E., et al., J. Biol. Chem. 270(35):20615-20620 (1995).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine
This PSMD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-377 amino acids from the C-terminal region of human PSMD4.
5710
26S proteasome non-ATPase regulatory subunit 4
PSMD4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
P55036
1709796
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cell Cycle
P55036
Optimal dilutions for each application to be determined by the researcher.