ProSci

SENP5 Antibody

Product Code:
 
PSI-57-708
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in K562 cell line lysates (35ug/lane).
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Western blot analysis in K562 cell line lysates (35ug/lane).

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PSI-57-708-400ul400ul£626.00
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Further Information

Additional Names:
Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, SENP5
Application Note:
For WB starting dilution is: 1:1000
Background:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).
Background References:
  • Yun, C., et al. J. Cell Biol. 183(4):589-595(2008)
  • Ding, X., et al. Oncol. Rep. 20(5):1041-1045(2008)
  • Gong, L., et al. J. Biol. Chem. 281(23):15869-15877(2006)
  • Di Bacco, A., et al. Mol. Cell. Biol. 26(12):4489-4498(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Mouse
Immunogen:
This SENP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-747 amino acids from the C-terminal region of human SENP5.
NCBI Gene ID #:
205564
NCBI Official Name:
Sentrin-specific protease 5
NCBI Official Symbol:
SENP5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
Q96HI0
Protein GI Number:
296452962
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q96HI0
User NOte:
Optimal dilutions for each application to be determined by the researcher.