ProSci

PITRM1 Antibody

Product Code:
 
PSI-56-391
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).

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PSI-56-391-400ul400ul£626.00
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Further Information

Additional Names:
Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1
Application Note:
For WB starting dilution is: 1:1000
Background:
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
Background References:
  • Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
  • Pinho, C.M., et al. Neurosci. Lett. 469(2):204-208(2010)
  • Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
  • Yoshida, T., et al. Int. J. Mol. Med. 24(4):539-547(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.
NCBI Gene ID #:
10531
NCBI Official Name:
Presequence protease, mitochondrial
NCBI Official Symbol:
PITRM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
117 kDa
Protein Accession #:
Q5JRX3
Protein GI Number:
485956568
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q5JRX3
User NOte:
Optimal dilutions for each application to be determined by the researcher.