ProSci

DMTF1 Antibody

Product Code:
 
PSI-59-362
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in U937 cell line lysates (35ug/lane).
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Western blot analysis in U937 cell line lysates (35ug/lane).

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PSI-59-362-400ul400ul£626.00
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Further Information

Additional Names:
Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Background References:
  • Liu, Y., et al. Mol. Psychiatry (2010) In press :
  • Sugiyama, T., et al. Expert Rev. Mol. Diagn. 8(4):435-447(2008)
  • Inoue, K., et al. Cancer Res. 68(12):4487-4490(2008)
  • Tschan, M.P., et al. Leukemia 22(5):1087-1090(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.
NCBI Gene ID #:
9988
NCBI Official Name:
Cyclin-D-binding Myb-like transcription factor 1
NCBI Official Symbol:
DMTF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Protein Accession #:
Q9Y222
Protein GI Number:
74762040
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9Y222
User NOte:
Optimal dilutions for each application to be determined by the researcher.