Further Information
Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, PTK2, FAK, FAK1
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
FAK1 is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of the gene encoding FAK1 may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix.
- Okamoto, H., et al., Hepatology 38(5):1242-1249 (2003).
- Moritake, H., et al., Cancer Genet. Cytogenet. 146(2):102-109 (2003).
- Liu, X.W., et al., J. Biol. Chem. 278(41):40364-40372 (2003).
- Avraham, H.K., et al., J. Biol. Chem. 278(38):36661-36668 (2003).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat, Xenopus
This FAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from human FAK1.
5747
Focal adhesion kinase 1
PTK2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
119 kDa
Q05397
3183518
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
Q05397
Optimal dilutions for each application to be determined by the researcher.