ProSci

LCP1 Antibody

Product Code:
 
PSI-60-157
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
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Western blot analysis in Jurkat cell line lysates (35ug/lane).

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PSI-60-157-400ul400ul£626.00
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Further Information

Additional Names:
Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1, LCP-1, LCP1, PLS2
Application Note:
For WB starting dilution is: 1:1000
Background:
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
Background References:
  • Wabnitz, G.H., et al. Eur. J. Immunol. 40(9):2437-2449(2010)
  • Janji, B., et al. J. Cell. Mol. Med. 14 (6A), 1264-1275 (2010) :
  • Le Goff, E., et al. Cytoskeleton (Hoboken) 67(5):286-296(2010)
  • Al Tanoury, Z., et al. PLoS ONE(2), E9210 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This LCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-335 amino acids from the Central region of human LCP1.
NCBI Gene ID #:
3936
NCBI Official Name:
Plastin-2
NCBI Official Symbol:
LCP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
Protein Accession #:
P13796
Protein GI Number:
308153685
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Signal Transduction
Swissprot #:
P13796
User NOte:
Optimal dilutions for each application to be determined by the researcher.