Further Information
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
For WB starting dilution is: 1:1000
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
- Lima,F.P., Am. J. Clin. Pathol. 129 (5), 723-726 (2008)
- Ida,C., Biosci. Biotechnol. Biochem. 72 (3), 868-871 (2008)
- Iijima,S., Eur. J. Biochem. 206 (2), 595-603 (1992)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
This MYC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from human MYC.
4609
Myc proto-oncogene protein
MYC
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
P01106
127619
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
P01106
Optimal dilutions for each application to be determined by the researcher.