Further Information
Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL1, ABL, JTK7
For WB starting dilution is: 1:1000
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
- Donaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99(22):14053-14058 (2002).
- Pisabarro, M.T., et al., J. Mol. Biol. 281(3):513-521 (1998).
- Nam, H.J., et al., Structure 4(9):1105-1114 (1996).
- Chissoe, S.L., et al., Genomics 27(1):67-82 (1995).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1.
25
Tyrosine-protein kinase ABL1
ABL1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
123 kDa
P00519
85681908
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
P00519
Optimal dilutions for each application to be determined by the researcher.