ProSci

RET Antibody

Product Code:
 
PSI-63-125
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of Ret Antibody (C-term T1078) in SKBR3 cell lysate
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Western blot analysis of Ret Antibody (C-term T1078) in SKBR3 cell lysate

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PSI-63-125-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment, RET, CDHF12, CDHR16, PTC, RET51
Application Note:
For WB starting dilution is: 1:1000
Background:
RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Background References:
  • Da Silva, A.M., et al., J. Clin. Endocrinol. Metab. 88(11):5438-5443 (2003).
  • McWhinney, S.R., et al., J. Clin. Endocrinol. Metab. 88(10):4911-4916 (2003).
  • D'Alessio, A., et al., Endocrinology 144(10):4298-4305 (2003).
  • Soares, P., et al., Oncogene 22(29):4578-4580 (2003).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1063-1093 amino acids from the C-terminal region of human RET.
NCBI Gene ID #:
5979
NCBI Official Name:
Proto-oncogene tyrosine-protein kinase receptor Ret
NCBI Official Symbol:
RET
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
124 kDa
Protein Accession #:
P07949
Protein GI Number:
547807
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Signal Transduction
Swissprot #:
P07949
User NOte:
Optimal dilutions for each application to be determined by the researcher.