Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Collagen alpha-2(I) chain, Alpha-2 type I collagen, COL1A2
For WB starting dilution is: 1:1000
This gene encodes the pro-alpha2 chain of type I collagen
whose triple helix comprises two alpha1 chains and one alpha2
chain. Type I is a fibril-forming collagen found in most connective
tissues and is abundant in bone, cornea, dermis and tendon.
Mutations in this gene are associated with osteogenesis imperfecta
types I-IV, Ehlers-Danlos syndrome type VIIB, recessive
Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and
atypical Marfan syndrome. Symptoms associated with mutations in
this gene, however, tend to be less severe than mutations in the
gene for the alpha1 chain of type I collagen (COL1A1) reflecting
the different role of alpha2 chains in matrix integrity. Three
transcripts, resulting from the use of alternate polyadenylation
signals, have been identified for this gene. [provided by R.
Dalgleish].
- Blades, H.Z., et al. Bone 47(5):989-994(2010)
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Bozec, A., et al. J. Cell Biol. 190(6):1093-1106(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This COL1A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human COL1A2.
1278
Collagen alpha-2(I) chain
COL1A2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
129 kDa
P08123
296439507
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
P08123
Optimal dilutions for each application to be determined by the researcher.