ProSci

HSD17B4 Antibody

Product Code:
 
PSI-56-474
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western blot analysis in MCF-7,ZR-75-1,HepG2 cell line lysates (35ug/lane).
2 / 2
HSD17B4 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis in MCF-7,ZR-75-1,HepG2 cell line lysates (35ug/lane).
HSD17B4 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

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PSI-56-474-400ul400ul£626.00
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Further Information

Additional Names:
Peroxisomal multifunctional enzyme type 2, MFE-2, 17-beta-hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, D-bifunctional protein, DBP, Multifunctional protein 2, MPF-2, (3R)-hydroxyacyl-CoA dehydrogenase, 111n12, Enoyl-CoA hydratase 2, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, HSD17B4, EDH17B4
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. [provided by RefSeq].
Background References:
  • Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Kashiwayama, Y., et al. J. Biol. Chem. 285(34):26315-26325(2010)
  • Pierce, S.B., et al. Am. J. Hum. Genet. 87(2):282-288(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HSD17B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the Central region of human HSD17B4.
NCBI Gene ID #:
3295
NCBI Official Name:
Peroxisomal multifunctional enzyme type 2
NCBI Official Symbol:
HSD17B4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
80 kDa
Protein Accession #:
P51659
Protein GI Number:
1706396
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P51659
User NOte:
Optimal dilutions for each application to be determined by the researcher.