Further Information
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase, CYP17A1, CYP17, S17AH
For IF starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in CYP17A1 gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
- Yuan,X., Cancer Epidemiol. Biomarkers Prev. 17 (12), 3621-3627 (2008)
- Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
- Imai,T., Hum. Genet. 89 (1), 95-96 (1992)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Monkey
This CYP17A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-388 amino acids from the Central region of human CYP17A1.
1586
Steroid 17-alpha-hydroxylase/17,20 lyase
CYP17A1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
P05093
117283
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Obesity,Signal Transduction
P05093
Optimal dilutions for each application to be determined by the researcher.