Further Information
Matrix metalloproteinase-24, MMP-24, 3424-, Membrane-type matrix metalloproteinase 5, MT-MMP 5, MTMMP5, Membrane-type-5 matrix metalloproteinase, MT5-MMP, MT5MMP, Processed matrix metalloproteinase-24, MMP24, MT5MMP
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).
- Jung, M., et al., Prostate 55(2):89-98 (2003).
- Kajita, M., et al., FEBS Lett. 457(3):353-356 (1999).
- Llano, E., et al., Cancer Res. 59(11):2570-2576 (1999).
- Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the Central region of human MMP24.
10893
Matrix metalloproteinase-24
MMP24
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
Q9Y5R2
12585280
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Cell Cycle,Neuroscience,Signal Transduction
Q9Y5R2
Optimal dilutions for each application to be determined by the researcher.