ProSci

TSG101 Antibody

Product Code:
 
PSI-61-117
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody is used in Western blot to detect TSG101 in ZR75-1 cell lysate
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Antibody is used in Western blot to detect TSG101 in ZR75-1 cell lysate

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PSI-61-117-400ul400ul£626.00
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Further Information

Additional Names:
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Application Note:
For WB starting dilution is: 1:1000
Background:
TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Background References:
  • Favre, M., et al., J. Acquir. Immune Defic. Syndr. 34(2):127-133 (2003).
  • Lu, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 100(13):7626-7631 (2003).
  • Goila-Gaur, R., et al., J. Virol. 77(11):6507-6519 (2003).
  • Blanco, S., et al., FEMS Microbiol. Lett. 221(2):151-154 (2003).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This TSG101 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-370 amino acids from the C-terminal region of human TSG101.
NCBI Gene ID #:
7251
NCBI Official Name:
Tumor susceptibility gene 101 protein
NCBI Official Symbol:
TSG101
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
Q99816
Protein GI Number:
9789790
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Cell Cycle,
Swissprot #:
Q99816
User NOte:
Optimal dilutions for each application to be determined by the researcher.