anti-PSD-95 (palmitoylated) mAb (rec.) (PF11)
Product Code:
AG-27B-0021
Antibody Clonality:
Recombinant Antibody
Target Species:- Bovine (Cattle)
- Human
- Mouse
Applications:- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
Storage:
Short Term: +4°C. Long Term: -20°C
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This product comes from:
Switzerland.
Typical lead time:
7-10 working days.
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Further Information
Alternate Names/Synonyms:
PSD95; Disks Large Homolog 4; DLG4; Postsynaptic Density Protein 95; Synapse-associated Protein 90; SAP90
0.5 mg/ml
32160000
liquid
Liquid. In PBS containing 10% glycerol.
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Palmitoylated PSD-95.
Recombinant Antibody. Recognizes human, mouse and rat palmitoylated PSD-95. Isotype: Human IgG2. Clone: PF11. Applications: ICC, IHC. Liquid. In PBS containing 10% glycerol. PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons.
anti-PSD95 Palmitoylated, mAb (rec.) (PF11) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain.
Plastic Vial
PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons.
>95% (SDS-PAGE)
Produced without the use of animals. Purified from HEK 293 cell culture supernatant.
Recognizes human, mouse and rat palmitoylated PSD-95.
Non-hazardous
Primary Antibodies
12352203
Stable for at least 1 year after receipt when stored at -20°C.