AdipoGen Life Sciences

GDC-046

Product Code:
 
SYN-1198
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
GDC046
Appearance:
Solid.
CAS:
1258292-64-6
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C16H13Cl2N3O2/c17-11-2-1-3-12(18)14(11)16(23)20-10-6-7-19-13(8-10)21-15(22)9-4-5-9/h1-3,6-9H,4-5H2,(H2,19,20,21,22,23)
InChiKey:
IAFNAEGXTKTGHN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1258292-64-6. Formula: C16H13Cl2N3O2. MW: 350.2. GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.
Molecular Formula:
C16H13Cl2N3O2
Molecular Weight:
350.2
Package Type:
Plastic Vial
Product Description:
GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Lead identification of novel and selective TYK2 inhibitors: J. Liang, et al.; Eur. J. Med. Chem. 67, 175 (2013)