Abnova Corporation

CD45RA monoclonal antibody, clone 111-1C5

Product Code:
 
MAB13412
Product Group:
 
Primary Antibodies
Supplier:
 
Abnova Corporation
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
111-1C5
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
 

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CodeSizePrice
MAB13412-100ug100 ug£488.00
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Further Information

Antigen Target Species:
Human
Form:
Liquid
Gene Alias:
B220|CD45|CD45R|GP180|LCA|LY5|T200
Gene Description:
protein tyrosine phosphatase, receptor type, C
Gene ID:
5788
Gene Name:
PTPRC
Immunogen:
Stimulated human leukocytes.
Product Description:
Mouse monoclonal antibody raised against native human CD45RA.
Recommend Dilutions:
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
Specificity:
Recognizes a protein of 205 kDa-220 kDa, identified as CD45RA (Workshop III). CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T cells, 50% of peripheral CD8+ T cells, B cells, and leukemic B cell lines. T cells expressing CD45RA are naive or virgin T cells. T cells expressing CD45RO are memory T cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T cells. This monoclonal antibody is useful in study on the subpopulation of CD4+ or CD8+ T cells. It can especially be used to differentiate T cell lymphomas (CD45RO+ve) from B cell lymphomas (CD45RA+ve).
Storage Buffer:
In 10 mM PBS.